Latino-style Salmon Fillet

Ingredients

1 banana leaf, cut into four 10″ x 12″ rectangles
4 salmon fillets
2 tomatoes, quartered
1 large white onion, julienned
2 jalapenos, seeded and sliced
1 red bell pepper, sliced
1½ cups grated cheddar oil for frying
salt and pepper to taste sugar for dusting

Mole Sauce

3 medium tomatillos, husked and rinsed
1/2 cup sesame seeds
1/2 cup pumpkin seeds
1/2 cup pork lard
1/2 cup mulato chiles, stemmed & seeded
1/4 cup ancho chiles
1/4 cup pasilla chiles
4 garlic cloves
1/2 cup almonds, skin on
1/2 cup raisins
1/2 Tbsp cinnamon
1/4 tsp pepper
1/4 tsp anise
1/8 tsp ground cloves
1 slice firm white bread toasted dark
1 ripened plantain, sliced
1 oz Mexican chocolate, chopped
4 tbsp brown sugar
8½ cups chicken broth salt to taste

Method

Mole Sauce

  1. Under oven broiler, roast tomatillos until blistered and soft. Scrape out juices and flesh into large bowl.
  2. In a dry skillet, toast sesame and pumpkin seeds over medium heat until golden brown. Add to bowl.
  3. In a large pot, add pork lard and warm over medium heat. Tear chillies into pieces and fry until interiors lighten in colour, about 30 seconds. Remove chiles from lard and place in a second bowl. Cover with hot tap water and let sit for 1 hour.
  4. In pot with pork lard, fry garlic and almonds for 5 minutes. Add to bowl with tomatillos. Repeat process with raisins until they are puffed and brown, about 30-50 seconds.
  5. In a blender, puree chillies with 3 cups of water until smooth. Remove from blender and set aside.
  6. Blend tomatillo mixture with 1½ cups of chicken stock and all remaining ingredients except stock, salt and sugar. Puree until smooth and return to bowl.
  7. In pot with pork lard, cook chili puree until mixture becomes dark and thick like tomato paste. Add tomatillo puree and continue cooking on medium low heat until mixture thickens, 35-40 minutes.
  8. Add remaining 7 cups of chicken stock and simmer on medium for 45 minutes.
  9. Season with salt and sugar.

Fish

  1. Preheat oven to 425ºF.
  2. Season salmon filets with salt and pepper. Dust with sugar.
  3. In a frying pan coated with oil, sear both sides of salmon filet.
  4. In frying pan, sauté bell pepper, onion, tomatoes and jalapenos until slightly softened, 2-3 minutes.
  5. Place each fillet on a banana leaf. Divide jalapeno mixture and cheese evenly among the filets. Wrap leaf to encase the salmon.
  6. Bake in oven for 8 minutes.
  7. Cut an incision in banana leaf and add mole sauce before serving.

Source: Ciao!

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New Method for Prostate Cancer Detection Can Save Millions of Men Painful Examination

A prostate image generated with the new technique. The red area indicates the tumor.

Each year prostate tissue samples are taken from over a million men – in most cases using 12 large biopsy needles – to check whether they have prostate cancer. This procedure, which was recently described by an American urology professor as ‘barbaric’1, shows that 70% of the subjects do not have cancer. A patient-friendly examination, which drastically reduces the need for biopsies has been developed at Eindhoven University of Technology (TU/e), together with AMC Amsterdam.

Hundreds of thousands of men die each year from prostate cancer. The standard procedure used worldwide for prostate cancer examinations starts with measurement of the PSA (prostate specific antigen) value in the blood. If this is high, physicians will usually remove samples of prostate tissue through the anus at six to sixteen points for pathological examination. However, 70% of the subjects show no signs of cancer. So does this mean the high PSA level is a false alarm? Not always: the biopsies may have been taken at just the wrong places. Cancer is later found in 30% of the patients with negative results (no cancer). Among the positive results (patients with signs of cancer), doctors do not know the exact sizes of the tumor. In many cases, operations show that the tumors are so small that surgery was unnecessary. As well as that, the examination leads to inflammations in up to 5% of patients. Plus the fact that each examination costs around USD 2500 to carry out.

Recognizable blood vessel pattern in cancer

Research team leader Massimo Mischi at TU/e has developed a method to investigate whether and where men have prostate cancer using existing ultrasound scanners, together with the Academic Medical Center Amsterdam. These devices create images of organs in the body using sound waves, in the same way as prenatal ultrasound scans. But these systems are usually unable to show the difference between healthy and tumor tissue. To make this visible, Mischi used the fact that tumor tissue produces large numbers of small blood vessels to allow it to grow, with a characteristic pattern. Patients are given a single injection of a contrast medium containing tiny bubbles, which are shown by the ultrasound scanner right down to the smallest blood vessels. Using advanced image-analysis techniques that can recognize the characteristic blood vessel pattern in tumors, the computer then generates an image showing where the tumor is. The examination only takes one minute, and the results are available no more than a few minutes later. These examinations also save money, because costly biopsy analysis is no longer necessary.

Precise prediction

The researchers were able to compare the ‘tumor images’ from 24 patients at three hospitals in the Netherlands with the actual prostates after removal by operation. The images were found to give a good indication of the locations and sizes of the tumors. Massimo Mischi will present the results at the European Association of Urologists Congress in Stockholm on 14 April. It is exceptional for a scientist from a university of technology to be given the opportunity to speak at this congress of medical specialists.

Far fewer biopsies

The use of the new method, which has been patented by TU/e, can avoid the need for biopsies to be taken from millions of men around the world. The procedure will no longer be necessary for a large part of the 70% of men from whom biopsies are currently taken unnecessarily. And far fewer biopsies will need to be taken from the remaining 30% because the location of the tumor is already clear. Once the new method has been sufficiently proven in clinical practice, the need to do biopsies may even be eliminated almost entirely.

Quick and simple introduction

The research is being carried out together with the Academic Medical Center Amsterdam and two other Dutch hospitals. A major comparative study will be held in these hospitals next year between the old and new methods, to proof that the new method is better. This will involve the use of both methods on at least 250 men. If all goes well the method will also be made available from 2016 for other patients, a large part of which will then no longer have to undergo the old and painful form of examination. The new method can be introduced quite simply because no new equipment is required; the existing ultrasound scanners which the hospitals already have can continue to be used.

Source: Eindhoven University of Technology


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