Grilled Lobster Italian-style

Ingredients

4 lobsters, each about 1½ pounds
6 strips bacon, each 12 inches long
2 tablespoons olive oil
8 red and yellow cherry tomatoes, halved for garnish

Saffron Tomato Sauce

2 tablespoons olive oil
2 teaspoon dried oregano
pinch saffron
15 ounces canned tomatoes, coarsely chopped
2 tablespoons white wine
salt and pepper, as needed

Roasted Pumpkin

2 cups pumpkin flesh, small-diced
1 tablespoon fresh mint, cut into chiffonade
1 tablespoon olive oil
1 teaspoon kosher salt

Lobster Salad

½ pound dry fregula
zest of ½ orange
½ cup Sicilian green olives, sliced lengthwise
2 tablespoons olive oil
2 tablespoons orange juice
2 teaspoons white wine vinegar
pinch red pepper flakes
½ tablespoon fresh mint, cut into chiffonade

Method

  1. Separate the heads, tails, and claws of the lobsters. Keep the heads for another recipe.
  2. Bring a pot of salted water to a boil. Blanch the tails for 1 minute and the claws for 4 minutes.
  3. Transfer the tails and claws to a bowl of ice water, and let cool.
  4. Shell the tails and then lightly score underneath so they stay flat. Reserve.
  5. Shell the claws and chop the lobster meat into medium-size chunks. Reserve.
  6. Wrap the reserve lobster tails in bacon and brush each with olive oil.
  7. Cook the tails on a grill over medium heat until well browned on all sides. If the bacon begins to burn on the grill, finish cooking on a rack in the oven. Let rest 2 minutes before slicing.

Saffron Tomato Sauce

  1. Place the olive oil, oregano, and saffron in a saucepan over low heat. Let infuse for 4 minutes. Add the white wine and reduce by half.
  2. Stir in the tomatoes and gently simmer for 15 minutes. Season to taste with salt and pepper.
  3. Blend the mixture with a hand blender. Reserve in a warm place for plating.

Roasted Pumpkin

  1. Place the pumpkin into an oven-safe dish, then toss with the mint and olive oil.
  2. Season with salt, then cook in a 350 degrees Fahrenheit oven until tender (about 15 minutes).

Lobster Salad

  1. Cook the fregula in salted boiling water until tender. Drain and let cool. Measure 1 cup of cooked pasta and reserve the rest for use in another recipe.
  2. In a bowl, combine the cooked pasta and the prepared roasted pumpkin, along with the orange zest, green olives, olive oil, orange juice, and white wine vinegar. Mix well and season to taste with salt and pepper.
  3. Add the prepared lobster claw meat, red pepper flakes, and mint. Toss again and reserve at room temperature.

Assembly

  1. Reheat the tomato sauce over low heat.
  2. Season the cherry tomatoes with salt.
  3. Slice the lobster tails into rounds.
  4. On each plate, spread a small amount of the tomato sauce, then arrange a lobster tail and some lobster salad in the center. Decorate with the cherry tomatoes and drizzle with olive oil.

Makes 4 Servings.

Source: Cognitive Cooking with Chef Watson – a collaboration between IBM and the Institute of Culinary Education

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Recurrence of Prostate Cancer Detected Earlier with Innovative PSMA-ligand PET/CT

A recent study reported in The Journal of Nuclear Medicine compared use of the novel Ga-68-PSMA-ligand PET/CT with other imaging methods and found that it had substantially higher detection rates of prostate-specific membrane antigen (PSMA) in patients with biochemical recurrence after radical prostatectomy. Discovering a recurrence early can strongly influence further clinical management, so it is especially noteworthy that this hybrid PSMA-ligand identified a large number of positive findings in the clinically important range of low PSA-values (<0.5ng/mL).

According to the CDC, prostate cancer is the most common cancer among men in the United States, after non-melanoma skin cancer. While many men with prostate cancer die from other causes, prostate cancer remains one of the leading causes of cancer death among men of all races. Treatment and survival after recurrence depend on many factors, but early detection of the recurrence is certainly key.

Matthias Eiber, MD, corresponding author of the study, noted, “The study is the first to examine this highly promising PET tracer in the use of a homogeneous patient collective consisting of only those with biochemical recurrence after radical prostatectomy. It found superb detection rates compared to other tracers, like choline, or imaging modalities, like MRI. For patients, this means that the referring urologist can receive earlier and more precise information about the site and extent of metastatic disease. Physicians will also be better able estimate whether a PSMA-PET scan might be useful in a specific setting.”

The study evaluated 248 patients with biochemical recurrence (median PSA level of 1.99ng/mL and a range of 0.2-59.4ng/mL) after radical prostatectomy. All were given contrast-enhanced PET/CT after injection of 155±27MBq Ga-68-PSMA-ligand. The detection rates were then correlated with PSA-level and PSA-kinetics. Influencing factors that were assessed include anti-hormonal treatment and primary Gleason score, as well as the contribution of PET and morphological imaging to the final diagnosis.

For 222 (89.5 percent) of the patients, the test detected higher than normal levels of PSMA. Whereas detection rates increased with higher PSA-velocity, no significant association could be found for PSA doubling-time.

In addition, the exciting news is that Ga-68-PSMA-ligand PET (compared to CT) exclusively provided pathological findings in 81 (32.7 percent) patients. In 61 (24.6 percent) patients, it exclusively identified additional involved regions. And, for those with a higher Gleason score (≤7vs.≥8), detection efficacy was significantly increased (P = 0.0190).

Dr. Eiber stated, “These findings will certainly enhance the use of PET in the diagnostic workup of patients with recurrent prostate cancer. When regulatory hurdles and reimbursement issues are overcome, this tracer might gain significant acceptance beyond Europe.”

Read more

Evaluation of Hybrid 68Ga-PSMA Ligand PET/CT in 248 Patients with Biochemical Recurrence After Radical Prostatectomy . . . . .

Source: Society of Nuclear Medicine and Molecular Imaging