Video: Three-course Meal Pizza

Each piece of this viral NYC pizza spot’s pie is loaded with appetizer, entree, and dessert. It’s designed so that as you eat your way up the slice, you’re going through each course in the same manner you’d normally get them at a restaurant.

Watch video (0:49 minutes) . . . . .

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Whole Cauliflower au Gratin

Ingredients

1 large head of cauliflower (1-1/2 to 2 lb)
1/4 cup water
2 Tbsp flour
1/3 cup plain yogurt
1 cup skim milk
1/2 cup shredded cheese
2 Tbsp gated Parmesan cheese
2 Tbsp dry bread crumbs

Method

  1. Pull off any outer green leaves from the head of cauliflower. Cut off protruding stem end close to the head, making it even with the bottom of the head of cauliflower. Cut a 1/2-inch deep “X” in the base of the cauliflower. Place cauliflower, flower side down, and water in a large microwaveable bowl. Cover with plastic wrap. Microwave on HIGH 10 minutes or until tender.
  2. Remove and let stand, covered for 5 minutes.
  3. Whisk together yogurt and flour until well blended. Gradually add milk, whisking until all ingredients are well blended. Microwave 3-4 minutes or until thickened, stirring after 2 minutes.
  4. Remove from microwave and add shredded cheese. Stir until cheese melted.
  5. Place cauliflower in shallow casserole dish and pour sauce over.
  6. Mix Parmesan cheese and bread crumbs together. Sprinkle over cauliflower. Broil for 2-3 minutes in the oven until topping is lightly browned. Serve hot with cooked Brussels sprouts and canned stewed tomato.

Makes 12 servings of side dish (about 1/2 cup each).

Source: Canadian magazine

In Pictures: Avocado Pasta

Grapefruit Juice and Some Drugs Don’t Mix

Grapefruit juice and the actual grapefruit can be part of a healthy diet. Grapefruit has vitamin C and potassium—nutrients your body needs to work properly.

But it isn’t good for you when it affects the way your medicines work, especially if you have high blood pressure or arrhythmia (irregular or abnormal heart beat).

This food and drug interaction can be a concern, says Shiew Mei Huang, PhD, of the U.S. Food and Drug Administration. The FDA has required that some prescription and over-the-counter (OTC) drugs taken by mouth include warnings against drinking grapefruit juice or eating grapefruit while taking the drug, Huang says.

Here are examples of some types of drugs that grapefruit juice can cause problems with (interact):

  • Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin).
  • Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine).
  • Some organ-transplant rejection drugs, such as Sandimmune and Neoral (both cyclosporine).
  • Some anti-anxiety drugs, such as buspirone.
  • Some corticosteroids that treat Crohn’s disease or ulcerative colitis, such as Entocort EC and Uceris (both budesonide).
  • Some drugs that treat abnormal heart rhythms, such as Pacerone and Nexterone (both amiodarone).
  • Some antihistamines, such as Allegra (fexofenadine).

Grapefruit juice does not affect all the drugs in the categories above. The severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink. Talk to your doctor, pharmacist or other health care provider and read any information provided with your prescription or OTC drug to find out:

  • If your specific drug may be affected.
  • How much, if any, grapefruit juice you can have.
  • What other fruits or juices may also affect your drug in a similar way to grapefruit juice.

b>How Grapefruit Juice Can Interfere With Medications

With most drugs that interact with grapefruit juice, “the juice lets more of the drug enter the blood,” Huang says. “When there is too much drug in the blood, you may have more side effects.”

For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure.

Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.

The amount of the CYP3A4 enzyme in the intestine varies from person to person, says Huang. Some people have a lot of enzymes and others just a little. So grapefruit juice may affect people differently even when they take the same drug.

Although scientists have known for several decades that grapefruit juice can cause too much of certain drugs in the body, Huang says more recent studies have found that the juice has the opposite effect on a few other drugs.

“Grapefruit juice can cause less fexofenadine to enter the blood,” decreasing how well the drug works, Huang says. Fexofenadine (brand name Allegra) is available as both prescription and OTC to relieve symptoms of seasonal allergies. Fexofenadine may also not work as well if taken with orange or apple juice, so the drug label states “do not take with fruit juices.”

Why this opposite effect? Instead of changing metabolism, grapefruit juice can affect proteins in the body known as drug transporters, which help move a drug into our cells for absorption. As a result, less of the drug enters the blood and the drug may not work as well, Huang says.

How Grapefruit Juice Affects Some Drugs

When drugs are swallowed, they may be broken down (metabolized) by enzymes and/or absorbed using transporters in cells found in the small intestine. Grapefruit juice can cause problems with these enzymes and transporters, causing too much or too little drug in the body.

Some drugs, like statins used to lower cholesterol, are broken down by enzymes. Grapefruit juice can block the action of these enzymes, increasing the amount of drug in the body and may cause more side effects.

Other drugs, like Allegra (fexofenadine) used to treat allergies, are moved by transporters into the body’s cells. Grapefruit juice can block the action of transporters, decreasing the amount of drug in the body and may cause the drug to not work as well.

Find Out if You Should Avoid Grapefruit or Other Juices

  • Ask your doctor, pharmacist or other health care provider if you can drink grapefruit juice while taking your medication.
  • Read the medication guide or patient information sheet that comes with your prescription drug to find out if grapefruit juice affects your drug.
  • Read the Drug Facts label on your OTC drug, which will say whether you shouldn’t have grapefruit or other fruit juices with it.
  • If you must avoid grapefruit juice with your medicine, check the labels of fruit juices or drinks flavored with fruit juice to see whether they are made with grapefruit juice.
  • Seville oranges (often used to make orange marmalade), pomelos, and tangelos (a cross between tangerines and grapefruit) may have the same effect as grapefruit juice. Do not eat those fruits if your medicine interacts with grapefruit juice.

Source: U.S. Food and Drug

Opinion: Most Women Should Forgo Ovarian Cancer Screening

The potential harms of ovarian cancer screening outweigh the benefits, so only very specific groups of women should be screened for the disease, the U.S. Preventive Services Task Force (USPSTF) says in a draft recommendation.

“The task force found that screening women without signs or symptoms for ovarian cancer does not decrease the number of deaths from the disease, and may lead to unnecessary surgeries,” Dr. Maureen Phipps said in a news release from the USPSTF.

“Therefore, the task force recommends against screening for ovarian cancer in women who have no signs or symptoms, and who are not at high risk for ovarian cancer,” she said. Phipps is a member of the task force, which is an independent, volunteer panel of national experts in prevention and evidence-based medicine.

The new guidance reaffirms a 2012 final recommendation made by the USPSTF.

Task force chair Dr. David Grossman said that “the current screening tests do not do a good job identifying whether a woman does or does not have ovarian cancer.”

The USPSTF “hopes that, in the future, better screening tests for ovarian cancer will be developed,” he added.

The draft recommendation statement and draft evidence review are posted for public comment on the task force website. Comments can be submitted from July 18 through Aug. 14.

Ovarian cancer is the eighth most common cancer and the fifth most common cause of cancer death among women in the United States, the USPSTF said.

Current screening tests for ovarian cancer aren’t very accurate, and may indicate a woman has ovarian cancer when she doesn’t, according to the task force. These false-positive tests can lead to unnecessary major surgery to remove one or both ovaries, the panel members said.

The USPSTF noted that no other major medical organization recommends screening for ovarian cancer among women in the general population.

Source: HealthDay


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