FDA Warns Long-term Risks with Antibiotic Clarithromycin (Biaxin) in Heart Disease Patients

The antibiotic clarithromycin (brand name: Biaxin) may increase the long-term risk of heart problems and death in patients with heart disease, according to U.S. health officials.

As a result, the federal Food and Drug Administration said Thursday that it’s recommending that doctors carefully weigh the benefits and risks of the drug before prescribing it to patients with heart problems.

The agency said its warning is based on a 10-year follow-up study of patients with coronary heart disease. The study found an unexpected and unexplained increase in deaths among heart disease patients who took clarithromycin for two weeks and were followed for one year or longer.

There’s no clear explanation for how clarithromycin would increase heart disease patients’ risk of death, the FDA said in a news release.

One heart specialist said this type of alert is worth heeding, however.

“It is important for health professionals and pharmacists to identify potential interactions between medications and eliminate prescription errors to prevent this risk,” said Dr. Marcin Kowalski. He directs cardiac electrophysiology at Staten Island University Hospital in New York City.

The FDA said it has added a new warning about this increased risk for heart patients, and is advising doctors to consider prescribing other antibiotics to these patients. The agency added that it will continue to monitor safety reports in patients taking clarithromycin.

The antibiotic is used to treat many types of infections affecting the skin, ears, sinuses, lungs and other parts of the body.

Doctors should talk to their heart patients about the risks and benefits of clarithromycin and alternative treatments. If doctors prescribe clarithromycin to patients with heart disease, they should inform those patients about the signs and symptoms of cardiovascular problems, the FDA said.

And patients with heart disease should tell their doctor about their condition, especially when they are being prescribed an antibiotic to treat an infection.

Heart disease patients should not stop taking their heart disease medicine or antibiotic without first talking to their doctor, the FDA said.

Patients taking the antibiotic should seek immediate medical attention if they experience symptoms of a heart attack or stroke, such as chest pain, shortness of breath or trouble breathing, pain or weakness in one part or side of the body, or slurred speech, the agency said.

Dr. Satjit Bhusri is a cardiologist at Lenox Hill Hospital in New York City.

He said, “Although this study suggests an association between this specific antibiotic, there have not been any direct correlations to increased heart disease.

“I would also extend this to all antibiotics in general. A short course of antibiotic therapy for a bacterial infection should be initiated if indicated by the physician; and a history of antibiotic therapy, at this time, should not be considered a risk factor for heart disease,” he said.

Source: HealthDay

Video: How to Make the Best Hot Chocolate

This video discusses the everyday chemistry of hot cocoa powder. From the chocolate mix to the milk, these science-inspired life hacks should help improve your cold weather pick-me-up.

Watch video at You Tube (3:04 minutes) . . . . .

Scallop Appetizer with Jalapeno Cream


2 tbsp seeded and finely chopped jalapeno pepper
1 garlic clove, minced
12 large scallops
pinches of salt and pepper (preferably white)
1 tbsp butter
1 firm ripe avocado
10 chives, chopped, or 1/2 cup coarsely chopped fresh cilantro
1 tsp freshly squeezed lemon juice
1/4 cup white wine
1/2 cup whipping cream
pinch of cayenne (optional)


  1. Prepare jalapeno and garlic.
  2. Pat scallops dry with paper towels. Lightly sprinkle both sides with salt and pepper.
  3. Melt butter in a large frying pan over medium-high heat. When bubbly, add scallops. Don’t crowd. You may have to cook them in two batches. Cook until a deep golden, 2 to 3 minutes per side. Remove to a plate and cover with foil. Repeat with any remaining scallops.
  4. Meanwhile, slice avocado in half. Discard pit, then peel. Dice into small pieces. Place in a bowl. Stir in chives, lemon juice and a pinch of salt.
  5. When scallops have been removed, add wine, Jalapeno and garlic to pan. Using a wooden spoon, scrape up and stir in any brown bits. Boil down until about 1 tbsp remains, about 30 seconds.
  6. Add cream and cayenne. Boil, stirring occasionally until slightly thickened, 1 to 2 minutes.
  7. Return scallops and any juices to pan. Stir to coat.
  8. Spoon about 2 tbsp sauce onto each plate. Top with 3 scallops. Spoon avocado mixture overtop.

Makes 4 servings.

Source: Chatelaine

Cat Character Sweets

Opinion: Five Food and Nutrition Myths You Can Ignore

Jason Brick wrote . . . . . . .

A little more than 70% of American adults are overweight (according to the CDC), with a third of us qualifying as obese. But what if that has less to do with us jamming burgers into our faces and washing them down with sodas so big only astronomers understand how to measure their size and more to do with us having been lied to by the powers that be?

In search of answers to our various food-related conspiracy theories, we called up Dr. Walter Willett of the Harvard School of Public Health. Not only is he one of our leading experts in health, wellness, and nutrition, he’s spent a couple of decades calling out the most egregious food lies from government agencies and food cabals, and presenting more accurate information.

After talking with Dr. Willett, and reading his no-bullshit guide Eat, Drink, and Be Healthy, we identified the five most insidious food myths that have been forced down our throats and what we can do to combat them.

Myth #1: The Food Pyramid

If you’re old like me, you will remember “the Basic Four” food groups: dairy, meat, bread, and fruits and vegetables. It was an attempt by the US Department of Agriculture to provide guidelines for what to eat every day and introduced the concept of a balanced meal, but it wasn’t detailed enough to be useful. “It didn’t recognize a difference between white bread and whole grains, or between spinach and cherries,” says Dr. Willett.

The USDA addressed some of those concerns in the early 1990s with the more nuanced Food Pyramid, but, according to Dr. Willett, its legitimacy was undercut by lobbyists. “The influence of agribusiness like corn and dairy had more to do with [how the pyramid took shape] than the CDC and other health agencies,” says Willett. One example: the Food Pyramid wanted you to eat more white bread than raw vegetables. It also didn’t tell you the difference between good fats and oils and the bad ones.

The USDA’s latest nutrition guide, MyPyramid, introduced in 2011, is more trustworthy, but it’s also less nuanced and therefore brings back the issues associated with “the Basic Four.” For those looking for more detailed guidelines about what’s nutritional circa 2018, Dr. Willett recommends the Healthy Eating Plate, released by his team at the Harvard’s School of Public Health, which also provides an elaborate and nicely illustrated “Healthy Eating Pyramid,” complete with optional suggestions and reminders for what foods to eat sparingly.

Myth #2: Drink more milk

You heard it from your parents, from your TV, and from our buddy Leon the Professional: Milk is good for your bones and your teeth, so you should drink at least a glass a day. Maybe two. Especially as a kid. On the surface, this makes sense. Milk contains a lot of calcium. Calcium is what they make bones and teeth out of. Ergo, bones and teeth are made of milk. Pour me a glass!

According to Dr. Willett, though, it’s “not such an emergency.” A grip of studies during the ’90s looked at comparative medical outcomes in countries where people drink a lot of milk (like Denmark and the USA) and countries where people hardly drink any milk at all (like Japan and Singapore). Turns out, there’s not a whole lot of difference in frequency of broken bones, age of osteoporosis onset, or dental problems. If drinking a lot of milk was so important, we’d see more bone and tooth problems in the countries with less moo juice.

Why don’t we see that difference? Because calcium is in all kinds of stuff. Oranges, green beans, sunflower seeds, broccoli, almonds, squash, clams, and rockfish are just a few of the dozens of foods with a powerful calcium content. Hell, Tums have more calcium than your body needs.

The takeaway: Eat cheese because that shit is delicious, not because you’re afraid you’ll break a hip if you don’t.

Myth #3: Fat is bad

This one is rooted in the fitness craze in the ’70s and ’80s that accompanied jogging, jazzercising, and Jane Fonda’s Workout. Again, it made sense if you only gave it a little thought. Everyone wants to be thinner, and fat is the opposite of thin. So if we want to be thin, why would we put fat into our bodies?

But fat is one of three kinds of food substances our bodies need. Eating a diet with no fat is like running your car with no oil. Sure, you have plenty of gas and transmission fluid, but overall it’s a bad idea. Dr. Willett, and a few thousand other knowledgeable professionals, report that you shouldn’t avoid fats, but learn the differences between kinds of fat and eat accordingly. Roughly, these fall into three groups: good fats from plants and fish that you should eat plenty of; bad fats from animals (plus palm and coconut plants) that should represent no more than 10% of your daily caloric intake; and super-duper bad trans fats from industrial processes that you should not only avoid, but bury at a crossroads at midnight with a stake through their hearts.

There’s one piece of good news here. Back in the worst days of the fat scare, people ate butter substitutes made from trans fats and thought they were doing themselves a favor. According to Dr. Willett, “most butter substitutes are free of trans fats after we became aware of the problem in the early 2000s.” So, we’ve got that going for us.

Myth #4: Low-carb is good

Low-carb, slow-carb, Atkins, Paleo, or Keto. Whatever you choose to call it, low-carb diets are a massive business, and for two good reasons: 1) people who follow low-carb diets tend to experience rapid weight loss in the early months of the diet, which is not only encouraging, it’s usually pretty good for them, and 2) they generally don’t ask you to stop eating meat. Losing weight is good. Bacon is delicious. So what’s the problem?

“No diet advice is complete if you only tell people what not to eat,” says Dr. Willett. Breakfasts, lunches, and dinners consisting entirely of bacon and sawed-off chunks off cheese the size of a car battery is a staple of most low-carb diets, but your dietary approach needs to be far more complicated when you’re looking at the bigger picture.

But complicated nutrition programs don’t sell books, and you can’t make a Dr. Phil-esque comment that sums it up succinctly. So low-carb programs sell big and folks keep on being skinny right up to their first heart attack.

Myth #5: Diet soda makes you thin

“Oh, for the love of…” you’re saying. “Diet soda has zero calories. How can it not make you thin?”

That’s what the makers of diet sodas have been banking on (and taking to the bank) for decades. Like all the other myths on this list, it passes the sniff test initially because its surface thesis is sound: If you drink sodas with lots of sugar and calories, you’re going to put on more weight than if you drink sodas with zero calories.

But that’s not necessarily true, and despite a lot of research over the years on the matter, science isn’t entirely sure why yet. Some hypothesize that diet sodas contain a mess of chemicals that mess up your metabolism, make you crave sugar, or instruct your body to store fat. Other experts conjecture that it’s a correlation-not-causation thing — that only people who are already overweight drink diet sodas. Psychologists have speculated that some people might use consumption of diet drinks as tacit permission to super-size their value meal.

Yeah, it’s all super-complicated and nobody’s really sure what the hell is going on. Meanwhile, Dr. Willett recommends just setting the policy of never drinking calories. Water and tea are fine for most meals. Especially water. Drink more water.

Source: Thrillist