Video: The English House in Singapore – Chef Marco Pierre White’s First Restaurant in Asia

White’s first establishment in Asia is housed in adjoining 19th century shophouses along Singapore’s Mohamed Sultan Road, which were painstakingly restored over three years.

The property is inspired by colonial Singapore and houses stately dining rooms.

The English House will offer modern British cuisine and diners can tuck into dishes such as stuffed cabbage in a fresh tomato sauce, and platters of Black Angus beef ribs with braised spiced tendons and jus viande.

Watch video at You Tube (2:55 minutes) . . . . .

Advertisements

Healthy Chocolate-flavour Quinoa Pudding with Raspberries

Ingredients

2 tbsp unsweetened cocoa powder
3 tbsp granulated sugar
2 cups 1% milk
1/2 cup quinoa, rinsed and drained
1 cup fresh or frozen raspberries (thawed and drained, if frozen)
1/2 tsp vanilla extract

Method

  1. In a deep, medium-size saucepan, whisk together cocoa and sugar until well blended.
  2. Gradually whisk in milk. Stir in quinoa. Bring to a gentle boil over medium-high heat, stirring occasionally.
  3. Reduce heat to low, cover and simmer, stirring often, for 25 minutes or until quinoa is very soft tender and pudding is slightly thickened (the pudding will thicken considerably upon cooling).
  4. Remove from heat and stir in raspberries and vanilla. Let stand, covered, for 10 minutes.
  5. Serve hot, or let cool until warm or room temperature before serving. To serve cold, refrigerate in an airtight container for up to 2 days and serve.

Makes 5 servings.

Source: Heart and Stroke Foundation of Canada

In Pictures: The Food of London Steakhouse Co in London, U.K.

British Cuisine

The Restaurant – Owned by Chef Marco Pierre White

Do Lobsters Feel Pain When We Boil Them Alive?

The government of Switzerland has passed a law stating that as of March 1st, people there will no longer be able to put a live lobster into a pot of boiling water to cook it without stunning it first. Boiling live lobsters is the most popular way to cook them. We justify it with the thought that lobsters can’t feel pain like we do, but is that right? Can lobsters feel pain?

Dr. Robert Elwood, a professor emeritus of animal behaviour at Queen’s University Belfast, has spent the latter part of his career trying to figure out if there is such a thing as pain for lobsters. He says there’s been quite a bit of research in this area in the past 10 to 15 years and the evidence is stacking up. “We can’t prove pain in any animal species. You can only do studies and if they’re consistent with the idea of pain, you begin to think perhaps we should give them the benefit of the doubt. It’s what we call the precautionary principle and [it] gives them some protection in case they do feel pain.”

Probing for signs of pain

You can’t ask a lobster if it feels pain. There’s plenty of anecdotal evidence out there of lobsters that try to move away from heat, but it’s extremely difficult to know if that’s because of a reflex or if they truly are feeling the heat as pain.

“Pain is not something we perceive,” says Elwood. “It’s an interpretation of a nervous input.”

He first wanted to determine if crustaceans like lobster were acting by reflex. The first experiment he did was to put acid onto a prawn’s antenna to see what it would do. Prawns, like other decapod crustaceans such as crabs and lobsters, all have similar nervous systems.

“What I found was that the prawn would groom that specific antenna, not the alternative one. And that could be reduced if we applied to a local anesthetic. But they showed an awareness of the site of the acid and what they were doing was not consistent with the idea of a reflex.”

The lengths crustaceans will go to avoid a ‘painful’ stimulus

Another way scientists can try to tease apart whether a lobster is feeling pain is to look at motivational tradeoffs — what a crustacean will give up to avoid a noxious stimulus.

Elwood says, “A reflex will occur regardless of your motivation to do other things. If you tap someone’s knee and ankles on the foot to move by reflex, it’ll move the same way if they’re hungry or not. It doesn’t matter.”

His team ran a number of experiments where they gave shocks to hermit crabs, the crabs that inhabit empty gastropod shells.

“Now some crabs got out of the shell, but they were more likely to get out of an un-preferred type of shell than if they preferred that type of shell. They were trading off between keeping the good quality shell and avoiding the shock,” says Elwood. “The remarkable thing there is that they’re giving up an extremely valuable resource in order to escape the noxious stimulus, the electric shock.”

He says this is another bit of evidence that’s “consistent with the idea of pain” because humans, if they can, will also pay a lot of money to avoid pain.

Different nervous systems

One of the reasons it is so challenging to figure out definitively if crustaceans like lobsters experience pain like we do is because their nervous system is very different from those of vertebrates like us. Some scientists believe that since lobsters don’t have the same brain anatomy as we do, that they cannot feel pain.

Elwood thinks there’s a good chance that different animals, even with very different nervous systems, can perform the same functions. He gives the example of how lobster, octopus, and humans see.

“They all have parts of the brain devoted to analysis of visual stimuli, but they have independently evolved. They are completely different, but nevertheless they perform the same function. So it’s quite possible, given the utility of pain in promoting the fitness of animals, you could have the same function in completely different organisms.”

Weighing the evidence

“What we have is a list of criteria that you would expect to see of pain much beyond this is simple withdrawing or away from the subject,” says Elwood. “When you find that the animals fulfil those criteria, you are beginning to suspect that perhaps they might feel pain.”

But not everyone agrees.

Greg Irvine, the executive director of the Lobster Council of Canada, says, “This is an issue that’s come up several times over the last few years. And we take it very seriously in the lobster industry. We ensure that the lobster is well looked after from the catching through the shipping and holding and into storage and into use for consumers and restaurants. And we encourage people to properly look after them. The jury is still out. There’s no real scientific consensus on whether they feel pain if they’re boiled, but it’s the most traditional way to do it.”

Source: CBC

Study: Hormone Therapy Can Make Prostate Cancer Worse in Some Patients

Scientists at Cedars-Sinai have discovered how prostate cancer can sometimes withstand and outwit a standard hormone therapy, causing the cancer to spread. Their findings also point to a simple blood test that may help doctors predict when this type of hormone therapy resistance will occur.

Prostate cancer is the second-leading cause of cancer death in men, behind lung cancer, killing nearly 30,000 in the U.S. each year, according to the American Cancer Society. In its early stages, the most common type, adenocarcinoma, is curable and generally responds well to therapies, including those that target androgen—a male sex hormone that stimulates tumor growth.

However, in certain patients, the cancer becomes resistant to androgen-targeted therapy, and the cancer recurs or spreads. One possible reason for that resistance, the study indicated, appears to be that the therapy causes some adenocarcinoma cells to become neuroendocrine cancer-type cells—a rare type that normally appears in fewer than 1 percent of prostate cancer patients.

“This transformation is a problem because neuroendocrine prostate cancer is especially aggressive, metastasizes more readily and is more resistant to both androgen-targeted therapy and chemotherapy,” said Neil Bhowmick, PhD, co-director of the Cancer Biology Program at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai. He is senior author of the study, published in The Journal of Clinical Investigation, and Rajeev Mishra, PhD, former project scientist in his laboratory, is the lead author.

Bhowmick said about a fourth of the patients who receive androgen-targeted therapy may relapse with tumors that show features of neuroendocrine prostate cancer and develop treatment-resistant disease, according to published research.

To learn more about this process, the investigators examined how cancer cells interact with the supporting cells near the tumor, refered to as the tumor microenvironment, in laboratory mice. They found these interactions raised the level of the amino acid glutamine, turning the supporting cells into “factories” that supplied fuel for the cancer cells.

“While glutamine is known to spur cancer growth, its role in prostate cancer cells to trigger reprogramming of adenocarcinoma cells into neuroendocrine cancer cells is a new and important finding,” said Roberta Gottlieb, MD, professor of Medicine and vice chair of translational medicine in the Department of Biomedical Sciences at Cedars-Sinai. Gottlieb was a co-author of the study.

The team also examined how androgen-targeted therapy affected the cancer microenvironment.

“To our surprise, we found this type of therapy further changed the cellular environment in a way that caused adenocarcinoma cells in the prostate to transform into neuroendocrine cancer-type cells,” said Bhowmick, professor of Medicine and Biomedical Sciences.

As the final step in validating the findings in mice, investigators compared levels of glutamine in the plasma of small groups of patients—one with treatment-responsive prostate cancer and the other with treatment-resistant prostate cancer. They found that levels of glutamine were higher in the second group.

This finding has potential implications for treating prostate cancer patients, said Edwin Posadas, MD, co-director of the Translational Oncology Program at the cancer institute and associate professor and clinical chief of the Division of Hematology/Oncology in the Department of Medicine at Cedars-Sinai.

“The study raises the possibility that a simple blood test measuring glutamine might be able to pinpoint when androgen-targeted therapy is failing in a prostate cancer patient and even predict when therapy resistance will occur,” said Posadas, who co-authored the study. He said the team is designing a new study to test this hypothesis.

Source: Cedars-Sinai


Today’s Comic