New Buns with Sweet Fillings

Whipped Custard Cream Bun from 7-Eleven Japan

Tiramisu Bun from Lawson Japan

Classic Apple Pie


1 cup vegetable shortening
1/2 cup boiling water
1 tsp salt
3 cups sifted all-purpose flour


1/4 cup sugar
1 tbsp all-purpose flour
1/2 tsp ground cinnamon
1/4 tsp ground nutmeg
1/8 tsp salt
1 tbsp grated lemon rind
5 cups Washington State apple slices
1 tbsp lemon juice
2 tbsp butter or margarine


  1. To make the short pastry, preheat oven to 425ºF.
  2. Cream the shortening with boiling water until well mixed, either by hand or with an electric mixer.
  3. Add the salt and flour all at once and stir until thoroughly mixed.
  4. Form into a ball and chill in a covered container for at least an hour. Roll out half the dough for a single shell. Fit into a pie pan and then prick generously with a fork around edges and on bottom. Bake in the oven for 15 minutes for a single crust. Dough may be kept for at least 3 weeks in the refrigerator. Makes pastry for two 9-inch pie crusts.
  5. Preheat oven to 425ºF.
  6. Roll out half the pastry and line a 9-inch pie plate.
  7. Combine the sugar, flour, cinnamon, nutmeg, salt and lemon rind in a bowl. Add the apples and toss to coat evenly.
  8. Arrange the apples in the pastry-lined pie plate. Sprinkle with lemon juice and dot with butter.
  9. Roll out the remaining pastry and place over the apples. Cut air vents in the top. Trim the pastry and flute the edge, trimming any excess pastry.
  10. Bake for 40 to 45 minutes or until the crust is golden brown.

Makes 1 pie.

Source: The Creative Cooking Course

In Pictures: Eating Together Apart – Restaurants Reopen as Lockdowns Ease

Bangkok, Thailand

Amsterdam, Netherland

Tokyo, Japan

Beijing, China

Rome, Italy

View more pictures at Reuters . . . . .

New Imaging Tool Helps Researchers See Extent of Alzheimer’s Early Damage

Bill Hathaway wrote . . . . . . . . .

New imaging technology allows scientists to see the widespread loss of brain synapses in early stages of Alzheimer’s disease, a finding that one day may help aid in drug development, according to a new Yale University study.

The research, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, compared the density of synapses, which transmit signals between neighboring brain cells, in people with early stages of Alzheimer’s with those of people who have no evidence of the disease. As expected, the loss of synapses in those with an early stage of Alzheimer’s was particularly high in areas surrounding the hippocampus, an area of the brain crucial to formation of memory, the scientists report.

“However, our new methods enable us to detect widespread synaptic losses thoughout the brain,” said Yale’s Adam Mecca, assistant professor of psychiatry and first author of the paper. “This gives us confidence that we may use these results as a biomarker outcome for therapeutic trials, which could help speed development of new drugs to combat the disease.”

To get a clearer picture of the early effects of Alzheimer’s, the researchers used positron emission tomography (PET) imaging of a protein found in almost all brain synapses. Previous imaging technologies had been able to show in broad strokes the loss of brain tissue or reduced brain metabolism in Alzheimer’s. However, the new PET scans show the distribution of synaptic damage, a more specific disease pathology present at early stages of the disease, the authors say.

“These methods will allow us to examine synaptic loss at still earlier stages of disease — when people have evidence of Alzheimer’s pathogenesis but have not yet manifested symptoms,” said Christopher van Dyck, professor of psychiatry, neurology, and neuroscience, and senior author of the study.

Source: Yale University

Too Little Sleep Can Mean More Asthma Attacks in Adults

A good night’s sleep is crucial to good health. A new article in Annals of Allergy, Asthma and Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI) reveals that too little sleep, and occasionally too much sleep, can negatively impact adults with asthma.

“Previous research revealed that poor sleep quality has a negative effect on asthma symptoms in adolescents,” says Faith Luyster, PhD, lead author of the study. “Our study shows that adults with asthma are equally affected by too little (or sometimes too much) sleep. Compared to normal sleepers, short and long sleepers had a higher proportion of people who reported having an asthma attack in the past year (45 percent vs. 59 percent and 51 percent respectively) and had more days with impaired health-related quality of life. Impaired quality of life was characterized by more days of poor physical and mental health.

The study surveyed 1,389 adults who were 20 years and older who self-identified as having asthma. Of the group, 25.9 percent slept 5 hours or less, 65.9 percent slept 6-8 hours and 8.2 percent slept 9 or more hours. Sleep duration was measured by a single question, “How much sleep do you usually get at night on weekdays or workdays?” “Short sleepers” were more likely to be younger and non-White, while “long sleepers” were more likely to be older, female and a smoker.

Short sleepers, as compared to normal sleepers, had a greater likelihood of an asthma attack, dry cough, and an overnight hospitalization during the past year. Short sleepers also had significantly worse health related quality of life — including days of poor physical and mental health and inactive days due to poor health — and more frequent general healthcare use during the past year as compared to normal sleepers. The odds for long sleepers to have some activity limitation due to wheezing was higher when compared to normal sleepers. No significant differences in other patient-reported outcomes and healthcare use were observed between the long and normal sleepers.

“Disturbed sleep in an asthma patient can be a red flag indicating their asthma isn’t well-controlled,” says allergist Gailen D. Marshall, MD, PhD, ACAAI member and Editor-in-Chief of Annals. “This study adds solid evidence to the practice of asthma patients discussing sleep issues with their allergist to help determine if they need to change their asthma plan to achieve adequate sleep as a component of overall good asthma management. It also warns that consequences can be expected when sleep patterns are chronically inadequate.”

Source: American College of Allergy, Asthma & Immunology

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