Chuckles of the Day

 


Doctor

The man went to see his doctor because he was feeling under the weather.

The doctor asked the usual question such as had the man been drinking or eating too much.

“No,” said the man.

“Well, perhaps you have had too many late nights” queried the doctor.

“No,” the man replied.

The doctor thought about the problem for a while and then asked “much sex?”

“Infrequently,” came the reply.

“Is that two words or one?”

* * * * * * *

A woman went to her doctor to complain that her husband’s sexual feelings for her seemed to have declined.

The doctor, being an old friend of the family, gave the woman some pills to slip into her husband’s tea so that at least the man wouldn’t get a complex about being a bit under-powered.

Two days later, the woman was back in the doctor’s office.

“What happened?” asked the doctor. “Did the pills work?”

“Fantastic!” replied the woman. “I was so eager to see their effects on my husband that I tipped three of them into a cup of coffee and, within seconds of drinking it, he got up, kicked over the table and pulled me down on to the floor and ravished me.”

“Oh!” said the doctor. “I hope you weren’t too surprised.”

“Surprised?” said the woman. “I’ll never be able to set foot in that restaurant again . . . .”


Spiced French Toast with Seasonal Berries

Ingredients

4 eggs, plus 1 extra egg white
1/4 tsp ground cinnamon
1/4 tsp allspice
4 slices thick white bread
1 tbsp butter, melted

Berries

scant 1/2 cup superfine sugar
1/4 cup freshly squeezed
orange juice
scant 2 cups mixed seasonal berries, such as strawberries, raspberries, and blueberries

Method

  1. Preheat the oven to 425°F/220°C.
  2. Place the eggs and egg white in a large shallow bowl and whisk together with a fork. Add the cinnamon and allspice and whisk until combined.
  3. Soak the bread slices in the egg mixture for about 1 minute on each side. Brush a large baking sheet with the melted butter and place the bread slices on the sheet. Bake for 5-7 minutes, or until lightly browned. Turn the slices over and continue to bake for an additional 2-3 minutes.
  4. Meanwhile, place the sugar and orange juice in a medium pan and bring to a boil over low heat, stirring to dissolve the sugar. Add the berries, turn off the heat, and let cool for 10 minutes. Serve spooned over the toast.

Makes 4 servings.

Source: Brunch

In Pictures: Home-prepared Breakfast Toasts

Breakthrough Discovery to Transform Prostate Cancer Treatment

Zytiga, the drug to treat prostate cancerA novel formulation of the prostate cancer drug abiraterone acetate – currently marketed as Zytiga – will dramatically improve the quality of life for people suffering from prostate cancer, as pre-clinical trials by the University of South Australia show the new formulation improves the drug’s effectiveness by 40 per cent.

Developed by Professor Clive Prestidge’s Nanostructure and Drug Delivery research group at UniSA’s Cancer Research Institute, the breakthrough discovery uses an oil-based oral formulation that not only enables a smaller dose of the drug to be effective, but also has the potential to dramatically reduce possible side effects, such as joint swelling and diarrhoea.

Despite Zytiga being the leading formulation to treat prostate cancer, lead researcher, Dr Hayley Schultz says the new formulation will ultimately provide a better treatment for patients with prostate cancer.

Prostate cancer is the most commonly diagnosed cancer in men, with one in six at risk of diagnosis before the age of 85.

In 2019, more than 19,500 cases of prostate cancer were diagnosed in Australia. Globally, prostate cancer cases reached 1.28 million in 2018.

“Many drugs are poorly water soluble, so when they’re ingested, they enter the gut but don’t dissolve, which means that their therapeutic effect is limited,” Dr Schultz says.

“This is the case for Zytiga. Here, only 10 per cent of the dose is absorbed, leaving the other 90 per cent undissolved, where it simply passes through the body as waste.

“On top of this, patients taking Zytiga must fast for two hours prior to taking the drug, and another hour after taking the drug to achieve predictable absorption. And as you can imagine, this can be painstakingly inconvenient.

“Our new formulation changes this. By using oils to mimic pharmaceutical food effects, we’re able to significantly increase the drug’s solubilisation and absorption, making it more effective and a far less invasive treatment for patients.”

The new formulation uses very high levels of abiraterone acetate dissolved within a specific oil and encapsulated within porous silica microparticles to form a powder that can be made into tablets or filled into capsules. Applied to human treatment, it could reduce the dose from 1000mg to 700mg per day, without the need for fasting.

Prof Prestidge says if the team can secure funding, clinical trials in humans could be just two years away.

“Based on our knowledge of this drug’s pharmaceutical food effect, we hypothesise its absorption in humans will be extensively improved using this technology”, Prof Prestidge says.

“Anything we can do to contribute to the development of a commercialised product to improve the lives of patients, is invaluable.

“This novel formulation is flexible enough to be adopted by thousands of different medicines; its potential to help patients of all kinds is exponential.”

Source: University of South Australia

Hormones May Explain Greater Prevalence of Alzheimer’s in Women

Women have more Alzheimer’s disease-related changes in the brain than men, and this may be linked to hormonal disruptions at menopause, researchers say.

“About two-thirds of people living with Alzheimer’s are women, and the general thinking has been it’s because women tend to live longer,” said study author Lisa Mosconi of Weill Cornell Medicine in New York City.

“Our findings suggest that hormonal factors may predict who will have changes in the brain. Our results show changes in brain imaging features, or biomarkers in the brain, suggesting menopausal status may be the best predictor of Alzheimer’s-related brain changes in women,” Mosconi said.

The study included 85 women and 36 men, average age 52, with no thinking or memory problems.

Participants had brain scans to determine levels of Alzheimer’s-associated beta-amyloid plaques; volumes of gray and white matter; and the rate at which the brain metabolized glucose, an indication of brain activity.

Women scored worse on all the measures, the investigators found. Compared to men, women had an average of 30% more beta-amyloid plaques, and 22% lower glucose metabolism than the men did. The women also had 11% less gray and white matter volume than the men.

The study was published online in the journal Neurology.

“Our findings suggest that middle-aged women may be more at risk for the disease, perhaps because of lower levels of the hormone estrogen during and after menopause,” Mosconi said in a journal news release.

“While all sex hormones are likely involved, our findings suggest that declines in estrogen are involved in the Alzheimer’s biomarker abnormalities in women we observed. The pattern of gray matter loss in particular shows anatomical overlap with the brain estrogen network,” Mosconi said.

One limitation of the study is that it included only healthy, middle-aged people without severe brain or heart disease, said Mosconi. She added that larger studies that follow participants over a period of time are needed.

Source: HealthDay


Today’s Comic