Chuckles of the Day

 


Dorothy Parker was escorted to a New York party one evening by a young man of handsome, but haughty mien.

After dinner all the guests started to play the childish games that were the hallmark of these gatherings.

However, Mrs. Parker’s escort remained aloof and refused to join in.

Eventually she tried to persuade him herself, but he said:

“I can’t, I am afraid. I simply can’t bear fools.”

“How odd,” she replied. “Apparently your mother could.”

* * * * * * *

Some artists from the 1960s are re-releasing their hits with new lyrics to accommodate us — good news, for those feeling a little older and missing those great tunes.

Herman’s Hermits – “Mrs. Brown, You’ve Got A Lovely Walker”

The Bee Gees – “How Can You Mend A Broken Hip”

The Temptations – “Papa’s Got A Kidney Stone”

Ringo Starr – “I Get By With A Little Help From Depends”

Marvin Gaye – “I Heard It Through The Grape Nuts”

Procol Harem – “A Whiter Shade Of Hair”

Johnny Nash – “I Can’t See Clearly Now”

Leo Sayer – “You Make Me Feel Like Nappin'”

ABBA – “Denture Queen”

Paul Simon – “Fifty Ways To Lose Your Liver”

Roberta Flack – “The First Time I Ever Forgot Your Face”

Commodores – “Once, Twice, Three Times To The Bathroom”

Rolling Stones – “You Can’t Always Pee When You Want”

Bobby Darin – “Splish, Splash, I Was Having A Flash”



Pork and Fennel Meatball

Ingredients

2-1/2 teaspoons fennel seeds
2 teaspoons sea salt flakes
1 cup fresh breadcrumbs
1/4 cup milk
750 g ground pork
100 g piece flat pancetta, finely chopped
1/4 cup chopped flat-leaf parsley
olive oil, for cooking
crusty bread, olive tapenade, sliced tomato and arugula leaves, to serve

Method

  1. Preheat oven to 180°C (350°F).
  2. Place the fennel seeds and salt in a mortar and pestle and lightly crush.
  3. Place the breadcrumbs and milk in a bowl and stand for 5 minutes.
  4. Add the pork, pancetta, parsley and fennel-salt mixture and mix well for 2-3 minutes or until mixture comes together.
  5. Shape 1/3 cupfuls of the mixture into balls.
  6. Heat a non-stick frying pan over medium-high heat. Add a little oil to the pan and cook the meatballs, in batches, until well browned on all sides.
  7. Place on a baking tray and bake for 5-7 minutes or until cooked through.
  8. Serve the meatballs with crusty bread, olive tapenade, sliced tomato and arugula leaves.

Makes 4 servings.

Source: Fast, Fresh, Simple

New Cheese-filled Pizza Sub at Subway Japan

The single-serving new pizza sub is available nationwide from August 26 to October 6, 2020.

There are three types of topping:

  • Basil Tomato Chicken with basil and tomato sauce
  • Teri Mayo Chicken with 3 kinds of vegetables on chicken mixed with teriyaki sauce
  • Bacon Italiana with bacon, semi-dried sausage and tomato sauce.

On top of the meat and sauce is mixed cheese of Mozzarella and Gozza Maribo Red Cheddar.

The price of the new sub is 450 yen plus tax each.

Insights into Newly Characterized Form of Dementia

Hillary Smith wrote . . . . . . . . .

Working with their colleagues at the University of Pennsylvania, researchers at the University of Kentucky have found that they can differentiate between subtypes of dementia inducing brain disease.

“For the first time we created criteria that could differentiate between frontotemporal dementia (FTD) and a common Alzheimer’s ‘mimic’ called LATE disease,” said Dr. Peter Nelson of the Sanders-Brown Center on Aging at the University of Kentucky. He says they validated the criteria rigorously. The study was recently published in BRAIN: A Journal of Neurology. The first author of the paper was John L. Robinson from the University of Pennsylvania and the corresponding author was Nelson.

This work comes in the wake of a large group effort organized and funded by the National Institute on Aging, part of the National Institutes of Health (NIH), that helped define LATE, by an international team of experts including a strong contingent from U. Kentucky. LATE stands for “limbic-predominant age-related TDP-43 encephalopathy.” LATE is a disease with symptoms like Alzheimer’s disease, those symptoms are referred to as “dementia”, but is caused by different underlying processes in the brain.

LATE is important because it affects millions of people, approximately 40% of people over the age of 85. How was it recognized? Researchers around the world noticed that a large number of people who died in advanced age had symptoms of dementia without the telltale features of Alzheimer’s disease (“plaques and tangles”) in their brains at autopsy. Emerging research indicated that the protein TDP-43 contributed to that phenomenon.

“Dozens of different viruses and bacteria can cause pneumonia,” explained Nelson. “So why would we think there is just one cause of dementia?”

With that question in mind, Nelson and colleagues set out to define diagnostic criteria and other guidelines for advancing future research into this newly-named dementia.

“We used to think that aging-related memory and thinking decline meant one thing: a disease called Alzheimer’s disease. Now we know that the disease we were calling Alzheimer’s disease is actually many different conditions, often in combination.

“This raises some questions: Is it important to classify and differentiate those conditions? And, if so, how do we go about that?” Nelson said. “Cancer gives us inspiration, because in some ways that field of research is decades ahead of dementia research. In cancer, they found that different cancers are very different and respond differently to therapies, so it’s worthwhile figuring out the complexity. We are now focusing likewise on the different diseases that cause dementia. A type of protein deposits in the brain, called TDP-43, is very harmful to the brain and contributes to a dementia syndrome with memory loss and thinking problems.”

As researchers stated in this recent study, “There is a general agreement that millions of persons worldwide are affected by age-related TDP-43 proteinopathy.” However, there are some serious gaps in the classification guidelines for specific neurodegenerative disorders. That is why scientists wanted to closely compare frontotemporal dementia (FTD) and the mimic disease LATE. Ultimately, they found that the two do in fact have differentiating pathologic features.

“Until you can define a disease it’s very hard to look for a cure. Now we have a better basis to help work toward a therapy,” said Nelson.

With these findings now established Nelson is looking forward to working on the first clinical trial of LATE with his colleague at UK, Dr. Greg Jicha. “This is a very exciting opportunity to test a medicine that could stop the disease in its tracks, and to treat our research volunteers here at UK,” said Nelson.

Source: University of Kentucky

Yoga Linked with Improved Symptoms in Heart Patients

Sophia Antipolis wrote . . . . . . . . .

Yoga postures and breathing could help patients with atrial fibrillation manage their symptoms, according to research presented today at ESC Congress 2020.

Atrial fibrillation is the most common heart rhythm disorder. One in four middle-aged adults in Europe and the US will develop the condition, which causes 20–30% of all strokes and increases the risk of death by 1.5-fold in men and 2-fold in women. Reduced quality of life is common, and 10–40% of patients are hospitalised each year.

Symptoms of atrial fibrillation include palpitations, racing or irregular pulse, shortness of breath, tiredness, chest pain and dizziness.

“The symptoms of atrial fibrillation can be distressing. They come and go, causing many patients to feel anxious and limiting their ability to live a normal life,” said study author Dr. Naresh Sen of HG SMS Hospital, Jaipur, India.

This study investigated whether yoga could ease symptoms in patients with atrial fibrillation. The study enrolled 538 patients in 2012 to 2017. Patients served as their own controls. For 12 weeks they did no yoga, then for 16 weeks patients attended 30-minute yoga sessions every other day which included postures and breathing. During the yoga period, patients were also encouraged to practice the movements and breathing at home on a daily basis.

During both study periods, symptoms and episodes of atrial fibrillation were recorded in a diary. Some patients also wore a heart monitor to verify atrial fibrillation episodes. Patients completed an anxiety and depression survey3 and a questionnaire4 assessing their ability to do daily activities and socialise, energy levels and mood. Heart rate and blood pressure were also measured. The researchers then compared outcomes between the yoga and non-yoga periods.

During the 16-week yoga period, patients experienced significant improvements in all areas compared to the 12-week non-yoga period. For example, during the non-yoga period, patients experienced an average of 15 symptomatic episodes of atrial fibrillation compared to eight episodes during the yoga period. Average blood pressure was 11/6 mmHg lower after yoga training.

Dr. Sen said: “Our study suggests that yoga has wide-ranging physical and mental health benefits for patients with atrial fibrillation and could be added on top of usual therapies.”

Source: European Society of Cardiology


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