Character Donuts

Why Cotton Masks Are Safer Masks

Cotton masks provide better protection against the new coronavirus than those made with synthetic fabrics, researchers say.

In a new study, investigators tested different mask fabrics under conditions that mimic the humidity of a person's breath in order to assess how the fabrics perform in actual use.

Under humid conditions, filtration efficiency (a measure of how well a material captures particles) increased by an average 33% in cotton fabrics, according to the study published March 8 in the journal ACS Applied Nano Materials. That's because cotton is hydrophilic, meaning it attracts water. By absorbing small amounts of exhaled water in a person's breath, cotton fibers create a moist environment inside the fabric. That makes them more efficient filters compared to masks made of synthetic fibers.

In general, synthetic fabrics performed poorly in comparison to cotton, and their performance did not improve with humidity. Material used in medical masks was about as effective as cotton, but did not improve with humidity, the researchers said.

A previous study by the same team at the National Institute of Standards and Technology (NIST) and the Smithsonian's Museum Conservation Institute found that dual-layer masks made of tightly woven cotton fabrics with a raised nap, such as flannel, are particularly effective at filtering breath.

That study was conducted under relatively dry conditions in the lab.

"Cotton fabrics are still a great choice," said Christopher Zangmeister, a research scientist at NIST, in Gaithersburg, Md. "But this new study shows that cotton fabrics actually perform better in masks than we thought."

While the researchers found that humidity doesn't make it harder to breathe through fabric masks, breathing may become difficult if fabric masks get wet in other ways. They should be changed if they get wet due to weather.

The findings offer useful information for people who wear masks, as well as for scientists working to improve masks and measure their performance, the study authors said in an NIST news release.

"To understand how these materials perform in the real world, we need to study them under realistic conditions," Zangmeister said.

Source: HealthDay

In Pictures: Pancakes of Restaurants in London, U.K.

Ricotta hotcakes with honeycomb butter

Buckwheat galette with mushrooms, gruyère and spinach

Soft poached eggs, sweetcorn pancake and crispy pancetta

Pancakes with caramelised apples, lemon curd and custard

Vegan baby greens pancakes

Fluffy pancakes with berry compote and clotted cream

Could a New Drug Help Ease Alzheimer’s?

Dennis Thompson wrote . . . . . . . .

About 7 out of 10 Alzheimer’s patients wound up free of the brain plaques that are a hallmark of the disease after treatment with a potentially breakthrough experimental drug, clinical trial results show.

The drug, donanemab, also significantly slowed the patients’ brain decline, according to findings published March 13 in the New England Journal of Medicine.

Donanemab dissolves permanent plaque deposits of amyloid-beta, the toxic sticky protein that accumulates in the brains of people with Alzheimer’s, said study co-author Dr. Liana Apostolova, a professor of Alzheimer’s disease research at Indiana University School of Medicine.

The phase 2 clinical trial involved 257 patients, about half of whom received intravenous donanemab every four weeks for up to a year and a half. The other half received a placebo.

“The drug was extremely efficient in removing amyloid from the brain, so much so that by the end of the trial, 70% of individuals who entered with high levels of amyloid were essentially in the amyloid-negative range, which is really profound,” Apostolova said. “Such a percentage has not been reported today with other drugs that have successfully also removed amyloid, so that’s pretty remarkable.”

Alzheimer’s is characterized by buildup of a second kind of protein called tau, which forms “tangles” within the brain tissue of patients. Increasingly, scientists are realizing that tau could be an active player in Alzheimer’s disease. Donanemab does not target or treat the tau protein tangles that are a feature of later-stage Alzheimer’s, but researchers hope by flushing the brain of amyloid beta, they might prevent tau buildup as well, Apostolova said.

In this trial, donanemab worked so well that most patients were taken off it before the trial ended, Apostolova said.

“Greater than half of the participants were able to discontinue treatment because it worked so well, to the point where there was no point in giving it anymore because they were now essentially amyloid negative,” she said. “That’s huge.”

The drug also appeared to slow progression of Alzheimer’s, based on brain exercise tests, Apostolova said.

“The drug resulted in 32% better performance in those who take it compared to those who don’t,” she said. “Both groups declined, but the donanemab group declined 32% less, and that was significant.”

Not all brain exercise results were statistically significant, but they all tended to show a slowing of progression by 20% to 40%, Apostolova said.

The Alzheimer’s Association “is encouraged by these promising new data,” said Maria Carrillo, its chief science officer.

“These results are encouraging because it is the first phase 2 Alzheimer’s trial to show positive results on a primary outcome measure related to memory and thinking,” she said.

Carrillo added that “more work needs to be done on this experimental drug therapy,” noting that larger trials are needed to confirm the benefits of donanemab.

There were some troubling side effects that will need to be considered as donanemab rolls into phase 3 clinical trials. Those trials will determine whether the drug will be approved by the U.S. Food and Drug Administration.

The drug works by binding to mature amyloid plaques and dissolving them. The loose amyloid beta proteins are then removed from the brain through the blood vessels.

“When amyloid protein is removed from the brain through the blood vessels, it has to pass the blood-brain barrier, and that can cause a leakage in the barrier,” Apostolova said.

About a quarter of clinical trial participants experienced swelling of the brain due to micro-hemorrhages in tiny blood vessels, Apostolova said. Six percent developed symptoms related to this adverse effect. Symptoms can include headache, changes in mental state, confusion, vomiting, nausea, and difficulty walking.

Two individuals needed to be hospitalized due to brain swelling although both cases resolved themselves, the researchers said. Those people each had symptoms of confusion, and one person reported difficulty expressing herself.

There was one death reported among people taking donanemab, although it’s not clear that the drug was in any way responsible.

Still, “we would want to follow people with safety MRIs after starting a therapy like donanemab and make sure that they are safe to receive the drug and no such side effects occur,” Apostolova said.

She said future studies, including phase 3 trials, should focus on who might be at higher risk for brain swelling, and whether using a reduced dosage could avoid this risk.

Source: HealthDay

Banana Buckwheat Pancakes

Ingredients

3/4 cup buckwheat flour
3/4 cup white spelt flour
3 teaspoons baking powder
1 teaspoon ground cinnamon
3/4 cup mashed banana (about 3 bananas)
1 egg
1/4 cup maple syrup, plus extra to serve
3/4 cup milk
unsalted butter, to grease the pan
store-bought vanilla bean yoghurt, to serve
extra banana, sliced, to serve

Method

  1. Place both the flours, the baking powder and cinnamon in a large bowl and mix to combine.
  2. Add the banana, egg, maple syrup and milk and whisk until smooth.
  3. Heat a little of the butter in a non-stick frying pan over medium heat. Add 1/3 cup of the batter to the pan and cook for 2-3 minutes each side or until golden. Set aside and keep warm.
  4. Repeat with the butter and remaining batter.
  5. Divide pancakes between serving plates and top with yoghurt and extra banana. Drizzle with extra maple syrup to serve.

Makes 4 servings.

Source: A Fresher Approach to Eating


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