Seniors with Type 2 Diabetes May Have Increased Risk for Fracture

Though seniors with type 2 diabetes (T2D) tend to have normal or higher bone density than their peers, researchers have found that they are more likely to succumb to fractures than seniors without T2D. In a new study published in the Journal of Bone and Mineral Research, researchers from Hebrew SeniorLife’s Institute for Aging Research found older adults with type 2 diabetes had deficits in cortical bone–the dense outer surface of bone that forms a protective layer around the internal cavity– compared to non-diabetics. The findings suggest that the microarchitecture of cortical bone may be altered in seniors with T2D and thereby place them at increased risk of fracture.

Participants in this study included over 1,000 member of the Framingham Study who were examined over a period of 3 years. High resolution scanning allowed researchers to determine that many older adults with diabetes had weakness specific to cortical bone microarchitecture that cannot be measured by standard bone density testing.

Osteoporotic fractures are a significant public health problem that can lead to disability, decreased quality of life, and even death – not to mention significant health care costs. Risk of fracture is even greater in adults with T2D, including a 40 – 50% increased risk of hip fracture – the most serious of osteoporotic fractures.

“Fracture in older adults with type 2 diabetes is a highly important public health problem and will only increase with the aging of the population and growing epidemic of diabetes. Our findings identify skeletal deficits that may contribute to excess fracture risk in older adults with diabetes and may ultimately lead to new approaches to improve prevention and treatment,” said Dr. Elizabeth Samelson, lead author of the study.

Researchers hope that novel studies such as this will help to revolutionize the area of bone health, especially for older adults. It is important to follow screening guidelines for bone density testing, but better understanding of all the factors that affect bone strength and the tendency to fracture is needed.

Source: EurekAlert

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Proof that Magnesium Could Prevent Fractures

Magnesium could hold the key to preventing one of the most preventable causes of disability in middle-aged to elderly people, according to new research led by academics at the Universities of Bristol and Eastern Finland.

Bone fractures are one of the leading causes of disability and ill health especially among the ageing population and this increases the burden on the health care system. It is well-known that calcium and vitamin D play an important role in bone health. Magnesium is an essential nutrient and is an important component of the bone. Though there have been suggestions that magnesium may have a beneficial effect on bone health, no study has been able to show its effect on bone fractures.

Researchers at the Universities of Bristol and Eastern Finland followed 2,245 middle-aged men over a 20-year period. They found that men with lower blood levels of magnesium had an increased risk of fractures, particularly fractures of the hip. The risk of having a fracture was reduced by 44 per cent in men with higher blood levels of magnesium. None of the 22 men who had very high magnesium levels (> 2.3 mg/dl) in the study population experienced a fracture during the follow-up period. In the same study, dietary magnesium intake was not found to be linked with fractures. A finding that has been consistently demonstrated in several previous studies.

Dr Setor Kunutsor, Research Fellow from the University of Bristol’s Musculoskeletal Research Unit and lead researcher, said: “The findings do suggest that avoiding low serum concentrations of magnesium may be a promising though unproven strategy for risk prevention of fractures.”

Although blood levels of magnesium depend on magnesium intake from food and water, this may not be the case for the elderly, people with certain bowel disorders, and those on certain medications. For such people, increasing the intake of foods rich in magnesium may not necessarily increase blood magnesium levels. Treating the underlying conditions and magnesium supplementation may be another way of avoiding low blood levels of magnesium.

These new findings may have public health implications as low blood levels of magnesium are very common in the population. This is especially among middle-aged to elderly individuals who are also prone to fractures. Majority of these individuals do not experience any symptoms. Since blood magnesium is not measured routinely in the hospital, individuals with low levels of magnesium are very difficult to identify. These findings could help trigger initiatives to include blood magnesium screening in routine blood panels, especially for the elderly.

Professor Jari Laukkanen from the University of Eastern Finland and principal investigator, said: “The overall evidence suggests that increasing serum magnesium concentrations may protect against the future risk of fractures; however, well-designed magnesium supplementation trials are needed to investigate these potential therapeutic implications.”

Source: EurekAlert!