![](https://afp828.files.wordpress.com/2022/06/hflavo.jpg?w=468)
Sari Harrar wrote . . . . . . . . .
Regular consumption of food and drinks high in cell-protecting flavonoids—plant-based compounds found in fruit, vegetables, chocolate, and beverages such as red wine and tea—has been linked to fewer deaths among people with Parkinson’s disease, according to a study published in Neurology in March 2022. In an analysis of 599 women and 652 men with Parkinson’s who were tracked for an average of 33 years, those who consumed flavonoid-rich food and beverages three times a week were 26 to 40 percent less likely to die from any cause compared with those who had them less than once a month.
The subjects were enrolled in two long-running studies—the Nurses’ Health Study and the Health Professionals Follow-up Study—that have been tracking the health of middle-aged and older adults across the United States. Since the 1970s and 1980s, participants have completed questionnaires every two to four years about diet, exercise, sleep, and other lifestyle habits. For the Neurology report, researchers identified those who developed Parkinson’s disease, then analyzed their answers on food questionnaires to assess their intake of six major types of flavonoids. To determine deaths in this group, the researchers reviewed government records and reports from next of kin.
In addition to a lower death risk for those who ate the most flavonoids after their Parkinson’s disease diagnosis, the study found that men who consumed the most flavonoids before a Parkinson’s diagnosis also had a lower risk of death. This analysis joins an expanding pool of research uncovering promising associations for people with Parkinson’s disease.
“Adopting a healthy diet, high in colorful fruits and veggies, even after a Parkinson’s diagnosis, could slow disease progression and improve survival rates,” says lead author Xiang Gao, MD, PhD, chair of the department of nutrition and food hygiene at Fudan University’s School of Public Health in Shanghai (and previously on the faculty at Penn State). In a 2012 Neurology study, Dr. Gao and others found that higher flavonoid intake, particularly in men, reduced risk for developing Parkinson’s.
Flavonoids may protect the brain and body, and by extension reduce early death risk, in several ways, according to the Neurology study’s authors. They may tamp down the inflammation that contributes to the loss of dopamine-producing brain cells in Parkinson’s by mopping up cell-damaging free radicals. “In animal studies, polyphenols [beneficial plant compounds including flavonoids] have been shown to reduce the formation of alpha-synuclein, the sticky protein that clumps in the brains and bodies of those with Parkinson’s disease,” says Kellyann Niotis, MD, a neurologist at Weill Cornell Medicine in New York. Flavonoids also can help protect against high blood pressure, cardiovascular disease, stroke, cancer, depression, and cognitive decline—all of which contribute to the risk of dying in people with or without Parkinson’s disease.
The fact that food choices may influence the risk of Parkinson’s disease and end-of-life outcomes is significant, says Dr. Niotis, who focuses on risk-reduction strategies for patients with a family history of Alzheimer’s and Parkinson’s disease. “So many risk factors are nonmodifiable, such as age, sex, and genetics. This is an element that is potentially modifiable,” she says. “It is well known that both the Mediterranean and the MIND [Mediterranean-DASH Intervention for Neurodegenerative Delay] diets are associated with lower risk of Alzheimer’s disease,” she says, referring to two mostly plant-based diets. “But emerging research now supports their potential benefit in preventing and delaying the start of Parkinson’s. These diets may have a beneficial effect on brain health overall.”
While Dr. Niotis thinks the new study adds to existing knowledge, she notes some key limitations. It didn’t consider subtypes of Parkinson’s that lead to faster progression and more severe disease. It also didn’t look at diet and specific causes of death. People with the disorder are at higher risk for an earlier death for many reasons, including falls due to movement problems, pneumonia related to swallowing problems, and overall frailty, which can make even minor medical problems more serious. Reducing early mortality should be meaningful, Dr. Niotis says, but the study didn’t provide any information about the participants’ quality of life, which is an important component.
“There’s no magic bullet for preventing neurodegenerative diseases like Parkinson’s, but we all can make brain-healthier choices,” she says. “Adhering to a diet rich in antioxidants and flavonoids may positively affect Parkinson’s disease risk, trajectory, and related complications.”
The best way to add more flavonoids to your diet is through food, not supplements. “We don’t have enough evidence to support the consumption of flavonoid supplements to lower Parkinson’s disease risk or mortality,” Dr. Gao says.
These tips from Nicole Shuckett, RD, a registered dietitian in private practice in Toronto who specializes in nutrition and movement disorders, can help you increase your flavonoid intake.
Eat the rainbow. Choose a variety of fruits and vegetables in different colors to get a range of beneficial flavonoids, says Shuckett. In the analysis published in Neurology, people who got the most anthocyanins (from foods such as blueberries, cherries, cranberries, and red cabbage) and flavonols (found in apples, tea, bananas, peaches, and pears) had a 66 to 69 percent higher survival rate than those who ate the least. Add in flavonoid-rich ingredients by sprinkling chopped parsley on soup or squeezing lemon, lime, or orange juice into water.
Juice it up. “Smoothies can be loaded with berries, high-quality cocoa, and green leafy vegetables,” Dr. Niotis says. They are convenient for people with Parkinson’s disease or anyone else who has difficulty chewing, swallowing, or handling eating utensils, she adds.
Buy frozen versions. Frozen strawberries, blueberries, and raspberries may be less expensive than fresh berries and keep for months, Shuckett says. The same is true for frozen spinach, kale, and other leafy greens, which can be added to soups and stews.
Sip a cuppa. Black and green tea come from the same plant—camellia sinensis—and both deliver flavonoids called epicatechins. Steeping the tea in boiling water for five to 10 minutes increases the amount of antioxidants, according to a study published in Food Chemistry by researchers at Clarkson University in Potsdam, NY.
Make it a meal. Look for recipes that use tofu, black beans, cabbage, onions, tomatoes, and sweet peppers, either raw or cooked. They are all good sources of flavonoids, says Shuckett.
Savor red wine. Drinking three glasses of red wine per week was associated with lower mortality risk in the study, but alcohol’s not right for everyone. “A glass of red wine a couple of times a week is fine, as long as your doctor doesn’t advise against it,” Shuckett says.
Don’t forget dessert. Get flavonoids even in dessert by choosing one that includes dark chocolate or fruit, says Shuckett, who suggests pairing them for a sweet treat.
Source: Brain&Life
Filed under: Food, News and Articles, Nutrition | Tagged: Flavonoid, Parkinson's Disease | Comments Off on Food with Flavonoids May Reduce Risk of Parkinson’s Disease